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Detox Colon >> Causes & Diagnosis

Diseases of the colon

irritable bowel syndrome (spastic colon)
In medicine (gastroenterology), irritable bowel syndrome (IBS) is a group of functional bowel disorders which are fairly common and make up 20–50% of visits to a specialist.

Features:

Symptoms of IBS are abdominal pain or discomfort associated with changes in bowel habits in the absence of any structural abnormality. Colonic hypersensitivity is a sensitive but less specific sign of IBS. Depending on the kind of discomfort and bowel habits, IBS is also known as spastic colon, and can be subclassified into diarrhea-predominant (IBS-D), constipation-predominant (IBS-C) and IBS with alternating stool pattern (IBS-A). Typical is the overlap of IBS with chronic pelvic pain (this is probably due to misdiagnosis by the gynaecologist), fibromyalgia and mental disorder.

Treatment:

The most important therapeutic measure is reassuring the patient that he has no fatal or otherwise threatening disease, as this is the major concern of patients seeking medical help. Dependent on symptoms, treatment can consist of dietary advice, stool softeners and laxatives in obstipation-predominant, and antidiarrheals (loperamide) in diarrhea-predominant IBS. The use of antispasmodic drugs is not encouraged as the therapeutic benefit over placebo is hardly proven. Newer drugs include Alosetron and Tegaserod, both of which are heavily advertised but have only a limited effect. Psychotherapy is another treatment option, however many patients refuse to undertake one. Though not specifically indicated for IBS, the use of antidepressant drugs (e.g. amitriptyline in a low dosage or an SSRI) to treat the symptoms is common and has positive effects for some patients.

Prognosis:

IBS is not fatal nor is linked to the development of other serious bowel diseases. However, due to the chronic pain, discomfort and other symptoms, work absenteeism, social phobias and other negative quality-of-life effects can be common in more serious cases. Individuals lucky enough to find a successful treatment for their symptoms can lead normal lives.

Pathophysiology:

Research on the etiology of IBS has not yet brought forth unanimous results. Changes in colonic motility and immunologic causes have been discussed. Hypersensitivity of the gut is a major finding in IBS patients. The association of IBS with stress is less clear. About 50% of women with IBS report a history of sexual or physical abuse.

About 25% of patients develop symptoms after a hefty enteritis (partially after use of antibiotics, see also diarrhea). In these cases, a prolonged immune reaction is currently discussed as pathogenetic. So far, this is mainly based on experiments in the animal model.

IBS is widely regarded as a conglomeration of disorders with similar symptoms but a different etiology ("trash can"). As with many other medical conditions, there is a lot of speculation about causes, including in the field of alternative medicine.

http://en.wikipedia.org/wiki/Colon_(anatomy)


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